ARP5599P-11 [Polyclonal Antibody]
Phospho-MAPK8-Thr183/Tyr185 Rabbit Polyclonal Antibody
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Species:   Rabbit
Applications:   WB ELISA
Immunogen Range:   A synthetic phosphopeptide (conjugated with KLH) corresponding to residues surrounding T183/Y185 of human MAPK8
Clonality:   Polyclonal Antibody
Isotype:   /
GENE ID:   5599
Swiss Prot:   P45983
Synonyms:   JNK, JNK1, JNK1A2, JNK21B1/2, PRKM8, SAPK1
Purification:   Affinity purification
Storage:   Store at 4°C in PBS (0.2% gelatin, 0.1% sodium azide). Do not freeze.
Background:   The protein encoded by this gene is a member of the MAP kinase family. MAP kinases act as an integration point for multiple biochemical signals, and are involved in a wide variety of cellular processes such as proliferation, differentiation, transcription regulation and development. This kinase is activated by various cell stimuli, and targets specific transcription factors, and thus mediates immediate-early gene expression in response to cell stimuli. The activation of this kinase by tumor-necrosis factor alpha (TNF-alpha) is found to be required for TNF-alpha induced apoptosis. This kinase is also involved in UV radiation induced apoptosis, which is thought to be related to cytochrom c-mediated cell death pathway. Studies of the mouse counterpart of this gene suggested that this kinase play a key role in T cell proliferation, apoptosis and differentiation. Four alternatively spliced transcript variants encoding distinct isoforms have been reported. [provided by RefSeq
Caculated MW:   46,54 kDa
Observed MW:   Refer to Figures
Applications:   WB 1:200
Reacitivity:   Human, Mouse, Rat
For research use only. Not intended for diagnostic or therapeutic use!
Additional information