AMM920-13 [Monoclonal Antibody]
CD4 Mouse Monoclonal Antibody
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Species:   Mouse
Applications:   IP FC
Immunogen Range:   Native human peripheral blood leukemia T-cells
Clonality:   Monoclonal Antibody
Isotype:   IgM
GENE ID:   920
Swiss Prot:   P01730
Synonyms:   CD4mut
Purification:   Affinity purification
Storage:   Store at 4°C in PBS, pH 7.4 (15 mM sodium azide). Do not freeze.
Background:   Cluster of Differentiation 4 (CD4) is a glycoprotein composed of an amino-terminal extracellular domain (four domains: D1-D4 with Ig-like structures), a transmembrane part and a short cytoplasmic tail. CD4 is expressed on the surface of T helper cells, regulatory T cells, monocytes, macrophages and dendritic cells, and plays an important role in the development and activation of T cells. On T cells, CD4 is the co-receptor for the T cell receptor (TCR), and these two distinct structures recognize the Antigen–Major Histocompatibility Complex (MHC). Specifically, the D1 domain of CD4 interacts with the β2-domain of the MHC class II molecule. CD4 ensures specificity of the TCR–antigen interaction, prolongs the contact between the T cell and the antigen presenting cell and recruits the tyrosine kinase Lck, which is essential for T cell activation (1).
Caculated MW:   55 kDa
Observed MW:   Refer to Figures
Applications:   FC 10 ug/mL
Reacitivity:   Human
For research use only. Not intended for diagnostic or therapeutic use!
Additional information