AMM5788-15 [Monoclonal Antibody]
PTPRC Mouse Monoclonal Antibody
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Species:   Mouse
Applications:   ELISA FC
Immunogen Range:   A recombinant protein corresponding to amino acids 1029-1249 of human PTPRC
Clonality:   Monoclonal Antibody
Isotype:   IgG2b Kappa
GENE ID:   5788
Swiss Prot:   P08575
Synonyms:   B220, CD45, CD45R, GP180, LCA, LY5, T200
Purification:   Protein G purification
Storage:   Store at -20°C in PBS, pH 7.4 (0.1% sodium azide).Avoid freeze/thaw cycles.
Background:   The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP contains an extracellular domain, a single transmembrane segment and two tandem intracytoplasmic catalytic domains, and thus belongs to receptor type PTP. This gene is specifically expressed in hematopoietic cells. This PTP has been shown to be an essential regulator of T- and B-cell antigen receptor signaling. It functions through either direct interaction with components of the antigen receptor complexes, or by activating various Src family kinases required for the antigen receptor signaling. This PTP also suppresses JAK kinases, and thus functions as a regulator of cytokine receptor signaling. Four alternatively spliced transcripts variants of this gene, which encode distinct isoforms, have been reported. [provided by RefSeq
Caculated MW:   180-240 kDa
Observed MW:   Refer to Figures
Applications:  
Reacitivity:   Human
For research use only. Not intended for diagnostic or therapeutic use!
Additional information