AMMT015-11 [Monoclonal Antibody]
Ubiquitin Mouse Monoclonal Antibody
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Species:   Mouse
Applications:   WB ELISA IP
Immunogen Range:   A recombinant GST fusion protein corresponding to full length human Ubiquitin
Clonality:   Monoclonal Antibody
Isotype:   IgG1
GENE ID:   /
Swiss Prot:   /
Synonyms:   /
Purification:   Affinity purification
Storage:   Store at -20°C in HEPES, 150 mM NaCl (50% glycerol, 0.01% BSA, 0.03% sodium azide).Avoid freeze/thaw cycles.
Background:   Ubiquitin is a conserved polypeptide unit that plays an important role in the ubiquitin-proteasome pathway. Ubiquitin can be covalently linked to many cellular proteins by the ubiquitination process, which targets proteins for degradation by the 26S proteasome. Three components are involved in the target protein-ubiquitin conjugation process. Ubiquitin is first activated by forming a thiolester complex with the activation component E1; the activated ubiquitin is subsequently transferred to the ubiquitin-carrier protein E2, then from E2 to ubiquitin ligase E3 for final delivery to the epsilon-NH2 of the target protein lysine residue (1-3). The ubiquitin-proteasome pathway has been implicated in a wide range of normal biological processes and in disease-related abnormalities. Several proteins such as IκB, p53, cdc25A, and Bcl-2 have been shown to be targets for the ubiquitin-proteasome process as part of regulation of cell cycle progression, differentiation, cell stress response, and apoptosis (4-7).
Caculated MW:   18 kDa
Observed MW:   Refer to Figures
Applications:   WB 1:18000
Reacitivity:   Human
For research use only. Not intended for diagnostic or therapeutic use!
Additional information