AMM1031-11 [Monoclonal Antibody]
CDKN2C Mouse Monoclonal Antibody
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Species:   Mouse
Applications:   WB ELISA IP IF
Immunogen Range:   A recombinant protein corresponding to amino acids 18-530 of HA (A/Anhui/1/2005)(H5N1)
Clonality:   Monoclonal Antibody
Isotype:   IgG1
GENE ID:   1031
Swiss Prot:   P42773
Synonyms:   INK4C, p18, p18-INK4C
Purification:   Affinity purification
Storage:   Store at 4°C in PBS. Do not freeze.
Background:   Cyclin-dependent kinases (CDKs) are activated in part by forming complexes with cyclins. For example, CDK4 and CDK6 associate with the D-type cyclins and phosphorylate the retinoblastoma protein. This phosphorylation is a necessary event for cells to enter S-phase (1). The inhibitors of CDK4 (INK4) family include p15 INK4B, p16 INK4A, p18 INK4C and p19 INK4D. p18 has been shown to function as a haploinsufficient tumor suppressor in vivo (2). All INK4 proteins are composed of 32 amino acid ankyrin motifs and selectively inhibit CDK4/6 activity. Mutational analyses of p18 implicate the third and the amino-terminal portion of the fourth ankyrin repeat in mediating binding to CDK4/6 (3). The interaction of INK4 family members can be a binary complex with CDK4/6 or ternary complex with cyclin D-bound CDK4/6 and ultimately results in the inhibition of cell cycle progression (4,5).
Caculated MW:   18 kDa
Observed MW:   Refer to Figures
Applications:  
Reacitivity:   /
For research use only. Not intended for diagnostic or therapeutic use!
Additional information