AMM1026-11 [Monoclonal Antibody]
CDKN1A Mouse Monoclonal Antibody
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Species:   Mouse
Applications:   WB IHC ELISA ICC
Immunogen Range:   Native purified human CDKN1A
Clonality:   Monoclonal Antibody
Isotype:   IgG1
GENE ID:   1026
Swiss Prot:   P38936
Synonyms:   CAP20, CDKN1, CIP1, MDA-6, P21, SDI1, WAF1, p21CIP1
Purification:   Affinity purification
Storage:   Store at 4°C in PBS, pH 7.4 (15 mM sodium azide). Do not freeze.
Background:   This gene encodes a potent cyclin-dependent kinase inhibitor. The encoded protein binds to and inhibits the activity of cyclin-CDK2 or -CDK4 complexes, and thus functions as a regulator of cell cycle progression at G1. The expression of this gene is tightly controlled by the tumor suppressor protein p53, through which this protein mediates the p53-dependent cell cycle G1 phase arrest in response to a variety of stress stimuli. This protein can interact with proliferating cell nuclear antigen (PCNA), a DNA polymerase accessory factor, and plays a regulatory role in S phase DNA replication and DNA damage repair. This protein was reported to be specifically cleaved by CASP3-like caspases, which thus leads to a dramatic activation of CDK2, and may be instrumental in the execution of apoptosis following caspase activation. Two alternatively spliced variants, which encode an identical protein, have been reported. [provided by RefSeq
Caculated MW:   21 kDa
Observed MW:   Refer to Figures
Applications:  
Reacitivity:   Human
For research use only. Not intended for diagnostic or therapeutic use!
Additional information