AMM5175-11 [Monoclonal Antibody]
PECAM1 Mouse Monoclonal Antibody
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Species:   Mouse
Applications:   WB FC
Immunogen Range:   Native purified PECAM1 from leukocytes of a patient suffering from a LGL-type leukemia
Clonality:   Monoclonal Antibody
Isotype:   IgG1
GENE ID:   5175
Swiss Prot:   P16284
Synonyms:   CD31, PECAM-1
Purification:   Affinity purification
Storage:   Store at 4°C. For long term storage store at -20°C in PBS pH 7.4 (15 mM sodium azide). Avoid freeze/thaw cycles.
Background:   CD31 (Platelet Endothelial Cell Adhesion Molecule-1: PECAM-1), a member of the Ig superfamily of cell adhesion molecules, is expressed by circulating platelets, monocytes, neutrophils, some T cells and endothelial cells, and modulates cell adhesion, endothelial cell migration and angiogenesis (1). CD31 is phosphorylated on Tyr686 at the cytoplasmic carboxy-terminal tail upon various stimuli (e.g. mechanical stress or oxidative stress), presumably by Src family members (2). The tyrosine phosphorylation mediates associations with a number of SH2 domain containing binding partners such as PI3-kinase, SHIP, PLCγ and SHP-2. Thus, CD31 serves as a scaffold for various signaling molecules (3)
Caculated MW:   130 kDa
Observed MW:   Refer to Figures
Applications:  
Reacitivity:   Human
For research use only. Not intended for diagnostic or therapeutic use!
Additional information