AMM4311-11 [Monoclonal Antibody]
MME Mouse Monoclonal Antibody
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Species:   Mouse
Applications:   IP FC
Immunogen Range:   Native purified MME from human pre-B cell line NALM-6
Clonality:   Monoclonal Antibody
Isotype:   IgG1
GENE ID:   4311
Swiss Prot:   P08473
Synonyms:   CALLA, CD10, DKFZp686O16152, MGC126681, MGC126707, NEP
Purification:   Affinity purification
Storage:   Store at 4°C in PBS, pH 7.4 (15 mM sodium azide). Do not freeze.
Background:   This gene encodes a common acute lymphocytic leukemia antigen that is an important cell surface marker in the diagnosis of human acute lymphocytic leukemia (ALL). This protein is present on leukemic cells of pre-B phenotype, which represent 85% of cases of ALL. This protein is not restricted to leukemic cells, however, and is found on a variety of normal tissues. It is a glycoprotein that is particularly abundant in kidney, where it is present on the brush border of proximal tubules and on glomerular epithelium. The protein is a neutral endopeptidase that cleaves peptides at the amino side of hydrophobic residues and inactivates several peptide hormones including glucagon, enkephalins, substance P, neurotensin, oxytocin, and bradykinin. This gene, which encodes a 100-kD type II transmembrane glycoprotein, exists in a single copy of greater than 45 kb. The 5' untranslated region of this gene is alternatively spliced, resulting in four separate mRNA transcripts. The coding region is not affected by alternative splicing. [provided by RefSeq
Caculated MW:   100 kDa
Observed MW:   Refer to Figures
Applications:  
Reacitivity:   Human
For research use only. Not intended for diagnostic or therapeutic use!
Additional information