AMP92140-11
[Polyclonal Antibody]
MTDH Mouse Polyclonal Antibody
www.yhsbio.com
market@yhsbio.com
support@yhsbio.com
+86-21-54651191
Room 703,Building 6,333# Guiping
Rd.,Xuhui District,Shanghai,China
market@yhsbio.com
support@yhsbio.com
+86-21-54651191
Room 703,Building 6,333# Guiping
Rd.,Xuhui District,Shanghai,China
DATASHEET
| Species: | Mouse |
| Applications: | WB IF |
| Immunogen Range: | MTDH (NP_8489271, 1 aa ~ 582 aa) full-length human protein |
| Clonality: | Polyclonal Antibody |
| Isotype: | / |
| GENE ID: | 92140 |
| Swiss Prot: | Q86UE4 |
| Synonyms: | 3D3, AEG-1, AEG1, LYRIC |
| Purification: | Affinity purification |
| Storage: | Store at -20°C or lower in PBS(pH 7.4). Avoid freeze/thaw cycles. |
| Background: | Lyric/AEG-1 (Astrocyte Elevated Gene 1)/MTDH (Metadherin) was identified as a tight junction (TJ) protein based on its localization to TJ proteins in polarized epithelium. Differential subcellular localization and overexpression of Lyric/AEG-1/MTDH has been seen in multiple human cancers. Lyric/AEG-1/MTDH is involved in signaling pathways related to various cellular functions including proliferation and apoptosis/survival, and its alteration in cancer is associated with poor prognosis. In breast cancer, increased Lyric/AEG-1/MTDH may confer increased chemoresistance as well as metastasis. Lyric/AEG-1/MTDH expression is important in signaling and disease progression of hepatocellular carcinoma (HCC) and glioblastoma multiforme (GBM). |
| Caculated MW: | 65, 75 kDa |
| Observed MW: | Refer to Figures |
| Applications: | |
| Reacitivity: | Human |
For research use only. Not intended for diagnostic or therapeutic use!
Additional information