YRP11970-01 [Polyclonal Antibody]
SPOCK1/Testican 1 Rabbit Polyclonal Antibody
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Species:   Rabbit
Applications:   WB IHC IF
Immunogen Range:   KLH conjugated synthetic peptide derived from human SPOCK1/Testican 1
Clonality:   Polyclonal Antibody
Isotype:   IgG
GENE ID:  
Swiss Prot:  
Synonyms:   Sparc/osteonectin, cwcv and kazal like domains proteoglycan 1, SPOCK, Testican 1, Testican1, Testican-1;, TIC1, TICN1, TICN1_HUMAN.
Purification:   Purified by Protein A.
Storage:   Aqueous buffered solution containing 100ug/ml BSA, 50% glycerol and 0.09% sodium azide. Store at -20℃ for 12 months
Background:   The Testican family, also designated the BM-40/SPARC/osteonectin family, is composed of highly conserved, extracellular, calcium-binding, sulfate proteoglycans. Expression of Testicans is detected in a variety of tissues, but is most abundant in brain. Family members include Testican-1, Testican-2, Testican-3 and an amino-terminal splice variant of Testican-3, designated N-Tes. Most Testicans inhibit MT-MMPs, thereby inhibiting the activity of pro-MMP-2. Testican-1 is specifically expressed in the thalamus of the brain, and is upregulated in activated astroglial cells of the cerebrum where it mediates neuronal attachment and matrix metalloproteinase activation. After a neural injury, such as a cerebral stroke, Testican-1 expression is upregulated in astrocyte cells in order to inhibit the ability of the protein Neuro-2a to form neurite extensions. Testican-1 is also a component of joint and of the growth plate cartilage that may participate in the regulation of matrix turnover.
Caculated MW:   /
Observed MW:   Refer to Figures
Applications:   WB 1:100-1:1000
IHC 1:100-1:500
IF 1:50-1:200
Reacitivity:   Human, Mouse, Rat
For research use only. Not intended for diagnostic or therapeutic use!
Additional information