ARM64419-11 [Monoclonal Antibody]
MTMR14 Rabbit Monoclonal Antibody
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DATASHEET
Species:   Rabbit
Applications:   WB ELISA
Immunogen Range:   A synthetic peptide of human MTMR14 is used for rabbit immunization
Clonality:   Monoclonal Antibody
Isotype:   IgG
GENE ID:   64419
Swiss Prot:   Q8NCE2
Synonyms:   C3orf29, FLJ22405, FLJ46453, FLJ90311, HJUMPY, hEDTP
Purification:   Affinity purification
Storage:   Store at -20°C or lower in PBS(pH 7.4). Avoid freeze/thaw cycles.
Background:   Myotubularin-related protein 14 (MTMR14), also known as Jumpy, is a myotubularin-related phosphoinositol-3-phosphate (PI3P) phosphatase. Mutations in the MTMR14 gene have been associated with centronuclear myopathy. MTMR14 deficiency in mice leads to altered calcium homeostasis and muscle disorders. MTMR14 has also been shown to play a role in autophagy, a process that is highly regulated by phosphatidylinositides through the type III PI3K, Vps34. MTMR14 was localized to autophagic isolation membranes and early autophagosomes. In these studies, MTMR14 inhibited autophagy and mutations of MTMR14 associated with centronuclear myopathy were also defective in autophagy inhibition. In zebrafish, MTMR14 knockdown was shown to increase the number of autophagosomes, suggesting that its activity is associated with an inhibition of autophagy.
Caculated MW:   80 kDa
Observed MW:   Refer to Figures
Applications:  
Reacitivity:   Human
For research use only. Not intended for diagnostic or therapeutic use!
Additional information