ARP29760-11 [Polyclonal Antibody]
BLNK Rabbit Polyclonal Antibody
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Species:   Rabbit
Applications:   WB
Immunogen Range:   BLNK (AAH189061, 1 aa ~ 456 aa) full-length human protein
Clonality:   Polyclonal Antibody
Isotype:   /
GENE ID:   29760
Swiss Prot:   Q8WV28
Synonyms:   BASH, BLNK-S, LY57, MGC111051, SLP-65, SLP65
Purification:   Affinity purification
Storage:   Store at -20°C or lower in PBS(pH 7.4). Avoid freeze/thaw cycles.
Background:   This gene encodes a cytoplasmic linker or adaptor protein that plays a critical role in B cell development. This protein bridges B cell receptor-associated kinase activation with downstream signaling pathways, thereby affecting various biological functions. The phosphorylation of five tyrosine residues is necessary for this protein to nucleate distinct signaling effectors following B cell receptor activation. Mutations in this gene cause hypoglobulinemia and absent B cells, a disease in which the pro- to pre-B-cell transition is developmentally blocked. Deficiency in this protein has also been shown in some cases of pre-B acute lymphoblastic leukemia. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.
Caculated MW:   50.50 kDa
Observed MW:   Refer to Figures
Applications:  
Reacitivity:   Human, Rat
For research use only. Not intended for diagnostic or therapeutic use!
Additional information