AMM25937-11 [Monoclonal Antibody]
WWTR1 Mouse Monoclonal Antibody
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Species:   Mouse
Applications:   WB IHC S-ELISA ELISA
Immunogen Range:   WWTR1 (NP_0562871, 201 aa ~ 300 aa) partial recombinant protein with GST tag
Clonality:   Monoclonal Antibody
Isotype:   IgG2a Kappa
GENE ID:   25937
Swiss Prot:   Q9GZV5
Synonyms:   DKFZp586I1419, TAZ
Purification:   Affinity purification
Storage:   Store at -20°C or lower in PBS(pH 7.4). Avoid freeze/thaw cycles.
Background:   TAZ is a transcriptional co-activator with a PDZ-binding motif that is regulated by its interaction with 14-3-3 proteins (1). TAZ shares homology with the WW domain of Yes-associated protein (YAP). TAZ is proposed to modulate the switch between proliferation and differentiation of mesenchymal stem cells (MSC) via interaction with transcription factors Runx2 and PPARγ. This process is critical to normal tissue development and the prevention of tumor formation. Due to its role in determination of MSC fate, TAZ may have clinical relevance to several human diseases caused by an imbalance of MSC differentiation. TAZ appears to be negatively regulated by LATS tumor suppressor kinase, a component of the Hippo pathway that controls tissue growth and tumor development.
Caculated MW:   50 kDa
Observed MW:   Refer to Figures
Applications:  
Reacitivity:   Human
For research use only. Not intended for diagnostic or therapeutic use!
Additional information