ARM25851-11 [Monoclonal Antibody]
DKFZP434B0335 Rabbit Monoclonal Antibody
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Species:   Rabbit
Applications:   WB ELISA
Immunogen Range:   A synthetic peptide of human DKFZP434B0335 is used for rabbit immunization
Clonality:   Monoclonal Antibody
Isotype:   IgG
GENE ID:   25851
Swiss Prot:   Q7Z6L1
Synonyms:   FLJ23419, FLJ90593
Purification:   Affinity purification
Storage:   Store at -20°C or lower in PBS(pH 7.4). Avoid freeze/thaw cycles.
Background:   Tectonin β-propeller repeat protein (TECPR1) was first identified as DKFZP434B0335, a human ortholog of the yeast protein Pex23p. TECPR1 contains a pleckstrin homology (PH) domain, β-propeller domain, and dysferlin domains. Research studies have shown that elevated expression of TECPR1 may be a potential marker for prostate cancer (2). In several independent studies, TECPR1 was shown to play a role in autophagy through interaction with Atg5. Atg5 is a protein that is conjugated to the ubiquitin-like protein Atg12 and plays an essential role in autophagy. Initial studies suggested that TECPR1 plays a role in selective autophagy processes by targeting bacterial pathogens, as well as damaged mitochondria and protein aggregates. TECPR1 appears to be important for autophagosome maturation and promotes autophagosome fusion with the lysosome. Deletion of TECPR1 leads to an accumulation of autophagosomes.
Caculated MW:   130 kDa
Observed MW:   Refer to Figures
Applications:  
Reacitivity:   Human
For research use only. Not intended for diagnostic or therapeutic use!
Additional information