AMM23178-12 [Monoclonal Antibody]
PASK Mouse Monoclonal Antibody
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Species:   Mouse
Applications:   WB ELISA
Immunogen Range:   PASK (AAH63585, 1 aa ~ 100 aa) partial recombinant protein with GST tag
Clonality:   Monoclonal Antibody
Isotype:   IgM Kappa
GENE ID:   23178
Swiss Prot:   Q96RG2
Synonyms:   DKFZp434O051, DKFZp686P2031, KIAA0135, PASKIN, STK37
Purification:   Affinity purification
Storage:   Store at -20°C or lower in ascites fluid. Avoid freeze/thaw cycles.
Background:   PASK is a serine/threonine kinase that contains two PAS (Per-Arnt-Sim) domains. Its kinase activity is up-regulated by autophosphorylation of the activation loop within its catalytic domain and is inhibited in cis by one of the PAS domains. Studies found that the yeast homolog of PASK phosphorylates and inhibits two enzymes required for glycogen biosynthesis: UDP-glucose pyrophosphorylase and glycogen synthase, resulting in the decrease of carbohydrate storage. Further studies showed that increased glucose levels activate PASK activity and enhance its expression in pancreatic β-cells. PASK is essential for the glucose-stimulated expression of preproinsulin and Pdx1, suggesting its role in the regulation of genes involved in pancreatic β-cell functions. PASK was shown to be critical for glucose-stimulated insulin secretion in pancreatic β-cells. The absence of PASK also protects animals from obesity and insulin resistance when they are fed a high-fat diet. These findings suggest that PASK functions as an important metabolic sensor in various cells.
Caculated MW:   170 kDa
Observed MW:   Refer to Figures
Applications:  
Reacitivity:   Human
For research use only. Not intended for diagnostic or therapeutic use!
Additional information