ARP22941-11 [Polyclonal Antibody]
SHANK2 Rabbit Polyclonal Antibody
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Species:   Mouse
Applications:   WB ELISA
Immunogen Range:   SHANK2 (NP_036441, 1034 aa ~ 1124 aa) partial recombinant protein with GST tag
Clonality:   Polyclonal Antibody
Isotype:   /
GENE ID:   22941
Swiss Prot:   Q9UPX8-4
Synonyms:   CORTBP1, CTTNBP1, ProSAP1, SHANK, SPANK-3
Purification:   Affinity purification
Storage:   Store at -20°C or lower in 50% glycerol. Avoid freeze/thaw cycles.
Background:   This gene encodes a protein that is a member of the Shank family of synaptic proteins that may function as molecular scaffolds in the postsynaptic density (PSD). Shank proteins contain multiple domains for protein-protein interaction, including ankyrin repeats, an SH3 domain, a PSD-95/Dlg/ZO-1 domain, a sterile alpha motif domain, and a proline-rich region. This particular family member contains a PDZ domain, a consensus sequence for cortactin SH3 domain-binding peptides and a sterile alpha motif. The alternative splicing demonstrated in Shank genes has been suggested as a mechanism for regulating the molecular structure of Shank and the spectrum of Shank-interacting proteins in the PSDs of adult and developing brain. Two alternative splice variants, encoding distinct isoforms, are reported. Additional splice variants exist but their full-length nature has not been determined.
Caculated MW:   165 kDa
Observed MW:   Refer to Figures
Applications:  
Reacitivity:   Human
For research use only. Not intended for diagnostic or therapeutic use!
Additional information