AMM9788-11 [Monoclonal Antibody]
MTSS1 Mouse Monoclonal Antibody
www.yhsbio.com
market@yhsbio.com
support@yhsbio.com
+86-21-54651191
Room 703,Building 6,333# Guiping
Rd.,Xuhui District,Shanghai,China
DATASHEET
Species:   Mouse
Applications:   WB ELISA
Immunogen Range:   MTSS1 (AAH23998, 346 aa ~ 445 aa) partial recombinant protein with GST tag
Clonality:   Monoclonal Antibody
Isotype:   IgG1 Kappa
GENE ID:   9788
Swiss Prot:   O43312
Synonyms:   DKFZp781P2223, FLJ44694, KIAA0429, MIM, MIMA, MIMB
Purification:   Affinity purification
Storage:   Store at -20°C or lower in ascites fluid. Avoid freeze/thaw cycles.
Background:   Metastasis suppressor 1 (MTSS1) is a multi-functional scaffold protein that was initially discovered using a differential display technique that uncovered proteins missing from bladder cancer cell lines. MTSS1 (also known as Missing in Metastasis or MIM) is a cytoskeletal remodeling protein that contains a C-terminal WH2 actin-binding motif. Presence of an IMD (IRSp53/MIM homology) domain allows MTSS1 to induce F-actin bundling and filopodia formation in cells. MTSS1 binds to and activates Rac, a protein known to promote the formation of filopodia and lamellipodia. The receptor tyrosine phosphatase δ (PTPRD) is associated with MTSS1 and is required for MTSS1-dependent cytoskeletal change. MTSS1 is a Shh responsive gene that can help regulate Gli transcriptional activity. Transcription of MTSS1 is regulated by DNA methylation.
Caculated MW:   95-105 kDa
Observed MW:   Refer to Figures
Applications:  
Reacitivity:   Human
For research use only. Not intended for diagnostic or therapeutic use!
Additional information