YMP00029-01 [Polyclonal Antibody]
presenilin 1 Mouse Polyclonal Antibody
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Species:   Mouse
Applications:   WB IHC IF
Immunogen Range:   KLH conjugated synthetic peptide derived from rat presenilin 1
Clonality:   Polyclonal Antibody
Isotype:   IgG
GENE ID:   29192
Swiss Prot:   P97887
Synonyms:   Presenilin-1, PS-1, Protein S182, Psen1, Psnl1
Purification:   Purified by Protein A.
Storage:   Aqueous buffered solution containing 100ug/ml BSA, 50% glycerol and 0.09% sodium azide. Store at -20℃ for 12 months
Background:   Probable catalytic subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors and APP (beta-amyloid precursor protein). Requires the other members of the gamma-secretase complex to have a protease activity. May play a role in intracellular signaling and gene expression or in linking chromatin to the nuclear membrane. Stimulates cell-cell adhesion though its association with the E-cadherin/catenin complex. Under conditions of apoptosis or calcium influx, cleaves E-cadherin promoting the disassembly of the E-cadherin/catenin complex and increasing the pool of cytoplasmic beta-catenin, thus negatively regulating Wnt signaling. May also play a role in hematopoiesis (By similarity).
Caculated MW:   /
Observed MW:   Refer to Figures
Applications:   WB 1:100-1:1000
IHC 1:100-1:500
IF 1:50-1:200
Reacitivity:   Human, Rat, Rabbit
For research use only. Not intended for diagnostic or therapeutic use!
Additional information