AMM8115-15
[Monoclonal Antibody]
TCL1A Mouse Monoclonal Antibody
www.yhsbio.com
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support@yhsbio.com
+86-21-54651191
Room 703,Building 6,333# Guiping
Rd.,Xuhui District,Shanghai,China
DATASHEET
Species: |
Mouse |
Applications: |
WB S-ELISA ELISA IF |
Immunogen Range: |
TCL1A (NP_0688011, 61 aa ~ 114 aa) partial recombinant protein with GST tag |
Clonality: |
Monoclonal Antibody |
Isotype: |
IgG2b Kappa |
GENE ID: |
8115 |
Swiss Prot: |
P56279 |
Synonyms: |
TCL1 |
Purification: |
Affinity purification |
Storage: |
Store at -20°C or lower in PBS(pH 7.4). Avoid freeze/thaw cycles. |
Background: |
TCL1 (T cell leukemia 1), MTCP1 and TCL1b belong to the TCL1 proto-oncogene family, and their products are involved in Akt activation during embryonic development, T cell leukemias, prolymphocytic leukemias and B cell lymphomas. The Akt association domain of TCL1 binds with the PH domain of Akt. The formation of an oligomeric TCL-Akt complex is required for TCL1 coactivator function and results in phosphorylation and activation of Akt. Furthermore, functional analysis indicates that the interaction between TCL1 and Akt promotes translocation of Akt to the nucleus. These findings are supported by the crystal structure of TCL1, which suggests that TCL1 may participate in molecular transport. |
Caculated MW: |
14 kDa |
Observed MW: |
Refer to Figures |
Applications: |
|
Reacitivity: |
Human |
For research use only. Not intended for diagnostic or therapeutic use!