ARP7301-12 [Polyclonal Antibody]
TYRO3 Rabbit Polyclonal Antibody
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Species:   Rabbit
Applications:   WB
Immunogen Range:   TYRO3 (NP_0062842, 1 aa ~ 890 aa) full-length human protein
Clonality:   Polyclonal Antibody
Isotype:   /
GENE ID:   7301
Swiss Prot:   Q06418
Synonyms:   BYK, Brt, Dtk, FLJ16467, RSE, Sky, Tif
Purification:   Affinity purification
Storage:   Store at -20°C or lower in PBS(pH 7.4). Avoid freeze/thaw cycles.
Background:   Tyro3 is a receptor tyrosine kinase belonging to the TAM subfamily (Tyro3, Axl and Mer). All three members have similar domain structure composed of an extracellular region with 2 Ig-like domains, followed by 2 FNII-like domains, a single transmembrane region, and a cytoplasmic tyrosine kinase domain (1). The natural ligand for Tyro3, as well as Axl and Mer, is Gas6 (growth arrest-specific gene 6) (1,2). Expression pattern and target knockout data indicate an important role of Tyro3 in apoptotic cell phagocytosis of dendritic cells and macrophages (3), NK cell differentiation (4), reproductive neuron survival and migration (5), osteoclast stimulation (6,7), as well as cortical and hippocampal neuron function. Both MAPK and PI3K pathways have been suggested as downstream targets of Tyro3 activation (7,8). Tyro3 has also been shown to be correlated to melanoma tumorgenesis, likely through its reglulatory role in the expression of ongogenic microphthalmia-associated transcription factor (MITF).
Caculated MW:   110, 130 kDa
Observed MW:   Refer to Figures
Applications:  
Reacitivity:   Human, Mouse
For research use only. Not intended for diagnostic or therapeutic use!
Additional information