ARP7086-12 [Polyclonal Antibody]
TKT Rabbit Polyclonal Antibody
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Species:   Rabbit
Applications:   WB
Immunogen Range:   TKT (NP_0010551, 1 aa ~ 623 aa) full-length human protein
Clonality:   Polyclonal Antibody
Isotype:   /
GENE ID:   7086
Swiss Prot:   P29401
Synonyms:   FLJ34765, TKT1
Purification:   Affinity purification
Storage:   Store at -20°C or lower in PBS(pH 7.4). Avoid freeze/thaw cycles.
Background:   Transketolase (TKT) is a homodimer in the pentose phosphate pathway (PPP) that catalyzes the interketol transfer between ketoses and aldoses. This enzyme, along with transaldolase, connects the nonoxidative branch of the PPP with glycolysis. Several regions of TKT are evolutionarily conserved from gram-negative bacteria to mammals (3). There is evidence that hypoxic and non-hypoxic induction of HIF1-α increases the expression of TKT. Because cancer cells rely on TKT in altered cell metabolism for nucleic acid synthesis, work has been done to develop inhibitors of TKT as novel cancer treatments.
Caculated MW:   67.9 kDa
Observed MW:   Refer to Figures
Applications:  
Reacitivity:   Human
For research use only. Not intended for diagnostic or therapeutic use!
Additional information