AMM5970-11 [Monoclonal Antibody]
RELA Mouse Monoclonal Antibody
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Species:   Mouse
Applications:   WB ELISA
Immunogen Range:   RELA (NP_068810, 432 aa ~ 505 aa) partial recombinant protein with GST tag
Clonality:   Monoclonal Antibody
Isotype:   IgG1 Kappa
GENE ID:   5970
Swiss Prot:   Q04206
Synonyms:   MGC131774, NFKB3, p65
Purification:   Affinity purification
Storage:   Store at -20°C or lower in ascites fluid. Avoid freeze/thaw cycles.
Background:   NFKB1 or NFKB2 is bound to REL, RELA, or RELB to form the NFKB complex. The p50 (NFKB1)/p65 (RELA) heterodimer is the most abundant form of NFKB. The NFKB complex is inhibited by I-kappa-B proteins (NFKBIA or NFKBIB), which inactivate NFKB by trapping it in the cytoplasm. Phosphorylation of serine residues on the I-kappa-B proteins by kinases (IKBKA or IKBKB) marks them for destruction via the ubiquitination pathway, thereby allowing activation of the NFKB complex. Activated NFKB complex translocates into the nucleus and binds DNA at kappa-B-binding motifs such as 5-prime GGGRNNYYCC 3-prime or 5-prime HGGARNYYCC 3-prime (where H is A, C, or T; R is an A or G purine; and Y is a C or T pyrimidine).
Caculated MW:   65 kDa
Observed MW:   Refer to Figures
Applications:  
Reacitivity:   Human
For research use only. Not intended for diagnostic or therapeutic use!
Additional information