AMM5599-13 [Monoclonal Antibody]
MAPK8 Mouse Monoclonal Antibody
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Species:   Mouse
Applications:   WB IP ELISA
Immunogen Range:   MAPK8 (NP_620637, 318 aa ~ 427 aa) partial recombinant protein with GST tag
Clonality:   Monoclonal Antibody
Isotype:   IgG2a Kappa
GENE ID:   5599
Swiss Prot:   P45983
Synonyms:   JNK, JNK1, JNK1A2, JNK21B1/2, PRKM8, SAPK1
Purification:   Affinity purification
Storage:   Store at -20°C or lower in PBS(pH 7.4). Avoid freeze/thaw cycles.
Background:   The protein encoded by this gene is a member of the MAP kinase family. MAP kinases act as an integration point for multiple biochemical signals, and are involved in a wide variety of cellular processes such as proliferation, differentiation, transcription regulation and development. This kinase is activated by various cell stimuli, and targets specific transcription factors, and thus mediates immediate-early gene expression in response to cell stimuli. The activation of this kinase by tumor-necrosis factor alpha (TNF-alpha) is found to be required for TNF-alpha induced apoptosis. This kinase is also involved in UV radiation induced apoptosis, which is thought to be related to cytochrom c-mediated cell death pathway. Studies of the mouse counterpart of this gene suggested that this kinase play a key role in T cell proliferation, apoptosis and differentiation. Four alternatively spliced transcript variants encoding distinct isoforms have been reported.
Caculated MW:   48.3 kDa
Observed MW:   Refer to Figures
Applications:  
Reacitivity:   Human
For research use only. Not intended for diagnostic or therapeutic use!
Additional information