AMP3439-11 [Polyclonal Antibody]
IFNA1 Mouse Polyclonal Antibody
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Species:   Mouse
Applications:   WB
Immunogen Range:   IFNA1 (NP_0769181, 1 aa ~ 189 aa) full-length human protein
Clonality:   Polyclonal Antibody
Isotype:   /
GENE ID:   3439
Swiss Prot:   P01562
Synonyms:   IFL, IFN, IFN-ALPHA, IFNA13, IFNA, MGC138207, MGC138505, MGC13850
Purification:   Affinity purification
Storage:   Store at -20°C or lower in PBS(pH 7.4). Avoid freeze/thaw cycles.
Background:   Interferons (IFNs) appear both locally and systematically early after viral infection and participate in limiting the spread of infection. They also affect cell differentiation, growth, surface antigen expression and immunoregulation. There are three naturally occurring interferons: α, β and γ. IFN-α is derived from lymphoblastic tissue and has a number of therapeutic applications in the treatment of various human cancers and diseases of viral origin. Recombinant IFN-α from both natural and synthetic genes binds to a common cell surface receptor and induces antiviral activity in a variety of cell lines. When binding to discrete cell surface receptors on target cells, IFN-α induces rapid changes in Jak/Stat phosphorylation, which initiates the Jak/Stat signaling pathway. IFN-α signaling also involves production of DAG without an increased intracellular free calcium concentration and the subsequent activation of calcium-independent isoforms of PKC (β and ε) . All IFN-α signaling pathways lead to final alterations of gene expression, which mediate their pleiotropic biologic activities.
Caculated MW:   21.70 kDa
Observed MW:   Refer to Figures
Applications:  
Reacitivity:   Human
For research use only. Not intended for diagnostic or therapeutic use!
Additional information