YRP11925-01 [Polyclonal Antibody]
OTP Rabbit Polyclonal Antibody
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Species:   Rabbit
Applications:   WB IHC IF
Immunogen Range:   KLH conjugated synthetic peptide derived from human OTP
Clonality:   Polyclonal Antibody
Isotype:   IgG
GENE ID:  
Swiss Prot:  
Synonyms:   MGC3161, orthopedia homeobox, orthopedia homolog, OTP_HUMAN.
Purification:   Purified by Protein A.
Storage:   Aqueous buffered solution containing 100ug/ml BSA, 50% glycerol and 0.09% sodium azide. Store at -20℃ for 12 months
Background:   Homeodomain (HD) genes are helix-turn-helix transcription factors that play key roles in the specification of cell fates. OTP (orthopedia homeobox) is a 325 amino acid nuclear protein belonging to the paired homeobox family and Bicoid subfamily. OTP is expressed in neurons, which give rise to the paraventricular (PVN), supraoptic (SON), anterior periventricular (aPV) and arcuate (ARN) nuclei. Containing a homeobox DNA-binding domain and a OAR domain, OTP is suggested to be involved in the differentiation of hypothalamic neuroendocrine cells. At early embryonic stages in mice, the expression of SIM2 is downregulated in the absence of OTP, indicating a potential role for OTP as an upstream regulator of SIM2. OTP is highly conserved in evolution and is encoded by a gene located on human chromosome 5, which contains 181 million base pairs and comprises nearly 6% of the human genome.
Caculated MW:   /
Observed MW:   Refer to Figures
Applications:   WB 1:100-1:1000
IHC 1:100-1:500
IF 1:50-1:200
Reacitivity:   Human, Mouse, Rat
For research use only. Not intended for diagnostic or therapeutic use!
Additional information