AMP1244-11 [Polyclonal Antibody]
ABCC2 Rabbit Polyclonal Antibody
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Species:   Mouse
Applications:   ELISA
Immunogen Range:   ABCC2 (NP_000383, 214 aa ~ 313 aa) partial recombinant protein with GST tag
Clonality:   Polyclonal Antibody
Isotype:   /
GENE ID:   1244
Swiss Prot:   Q92887
Synonyms:   ABC30, CMOAT, DJS, KIAA1010, MRP2, cMRP
Purification:   Affinity purification
Storage:   Store at -20°C or lower in 50% glycerol. Avoid freeze/thaw cycles.
Background:   The protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the MRP subfamily which is involved in multi-drug resistance. This protein is expressed in the canalicular (apical) part of the hepatocyte and functions in biliary transport. Substrates include anticancer drugs such as vinblastine; therefore, this protein appears to contribute to drug resistance in mammalian cells. Several different mutations in this gene have been observed in patients with Dubin-Johnson syndrome (DJS), an autosomal recessive disorder characterized by conjugated hyperbilirubinemia.
Caculated MW:   >200 kDa
Observed MW:   Refer to Figures
Applications:  
Reacitivity:   Human
For research use only. Not intended for diagnostic or therapeutic use!
Additional information