YRP11845-01 [Polyclonal Antibody]
FEZ2/Zygin2 Rabbit Polyclonal Antibody
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Species:   Rabbit
Applications:   WB IHC IF
Immunogen Range:   KLH conjugated synthetic peptide derived from human FEZ2/Zygin2
Clonality:   Polyclonal Antibody
Isotype:   IgG
GENE ID:  
Swiss Prot:  
Synonyms:   Fasciculation and elongation protein zeta 2, Fasciculation and elongation protein zeta-2 , FEZ 2, Fez2, FEZ2_HUMAN, Highly similar to zyginII, HUM3CL, MGC117372, Pre T/NK cell associated protein, Zygin 2, Zygin II, Zygin-2.
Purification:   Purified by Protein A.
Storage:   Aqueous buffered solution containing 100ug/ml BSA, 50% glycerol and 0.09% sodium azide. Store at -20℃ for 12 months
Background:   Zygin 2 is a 353 amino acid cytoplasmic protein that belongs to the zygin family. Zygin 2 is found as a difulfide-linked homodimer but may for heterodimers with FEZ1. the plasma membrane to the cytoplasm by activation of PKC zeta. PKC zeta also enhances zygin 1 interaction with UFD2 and polyubiquitination. Expressed mainly in brain, zygin 1 is a mammalian ortholog of Caenorhabditis elegans UNC-76 and is able to restore partial locomotion and axonal fasciculation to C. elegans UNC-76 mutants, which suggest a functional role in axonal outgrowth. As component of the network of molecules that regulate cellular morphology and axon guidance machinery, zygin 1 may also be involved in microtubule associated transport and transcriptional regulation. Mutations in the gene encoding zygin 1 may be linked to the pathogenesis of schizophrenia. Zygin 1 exists as two alternatively spliced isoforms that are designated isoform long and isoform short.
Caculated MW:   /
Observed MW:   Refer to Figures
Applications:   WB 1:100-1:1000
IHC 1:100-1:500
IF 1:50-1:200
Reacitivity:   Human, Mouse, Rat
For research use only. Not intended for diagnostic or therapeutic use!
Additional information