ARP5170-62
[Polyclonal Antibody]
PDPK1 Rabbit Polyclonal Antibody
www.yhsbio.com
market@yhsbio.com
support@yhsbio.com
+86-21-54651191
Room 703,Building 6,333# Guiping
Rd.,Xuhui District,Shanghai,China
market@yhsbio.com
support@yhsbio.com
+86-21-54651191
Room 703,Building 6,333# Guiping
Rd.,Xuhui District,Shanghai,China
DATASHEET
| Species: | Rabbit |
| Applications: | WB IHC |
| Immunogen Range: | A recombinant protein of human PDPK1 |
| Clonality: | Polyclonal Antibody |
| Isotype: | IgG |
| GENE ID: | 5170 |
| Swiss Prot: | O15530 |
| Synonyms: | PDK1, PDPK2, PRO0461 |
| Purification: | Affinity purification |
| Storage: | Store at -20°C or -80°C in PBS with 0.02% sodium azide and 50% glycerol. Avoid freeze/thaw cycles. |
| Background: | The μ-opioid receptor (MOR) belongs to the superfamily of G-protein-coupled receptors. MOR mediates the analgesic and rewarding effects of morphine and other opiates as well as the actions of several endogenous opioid peptides. Upon binding to its ligands, this Gi-coupled receptor inactivates adenylyl cyclase and activates a variety of G-beta-gamma-dependent pathways including the MAPK and the PI3K/Akt cascades. Trafficking of these receptors to and from the plasma membrane and their desensitization play a significant role in morphine tolerance. As with other GPCRs, these processes are modulated by phosphorylation at diverse sites within intracellular domains. Among other sites, agonist-specific phosphorylation of serine 375 in mouse (serine 377 in human) MOR is essential for its internalization. |
| Caculated MW: | 63 kDa |
| Observed MW: | Refer to Figures |
| Applications: |
WB 1:500-1:2000 IHC 1:50-1:200 |
| Reacitivity: | Human, Mouse, Rat |
For research use only. Not intended for diagnostic or therapeutic use!
Additional information
