ARP245934-61 [Polyclonal Antibody]
DEFB121 Rabbit Polyclonal Antibody
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Species:   Rabbit
Applications:   WB IHC
Immunogen Range:   A recombinant protein of human DEFB121
Clonality:   Polyclonal Antibody
Isotype:   IgG
GENE ID:   245934
Swiss Prot:   Q5J5C9
Synonyms:   DEFB121, ESC42RELC
Purification:   Affinity purification
Storage:   Store at -20°C or -80°C in PBS with 0.02% sodium azide and 50% glycerol. Avoid freeze/thaw cycles.
Background:   ∫-defensins (also designated BDs, or hBDs in human) are small cationic peptides with broad-spectrum antimicrobial activity against a variety of enveloped viruses, fungi and bacteria. Produced in mucosal epithelia and neutrophils of several species, ∫-defensins are developmentally regulated. The family of ∫-defensin proteins share a common defensin-motif that is characterized by multiple cysteine residues and a highly conserved tertiary structure. Besides playing a significant role in host immune defense, many ∫-defensins also are involved in sperm maturation and capacitation. ∫-defensin 121 is a 76 amino acid secreted protein that most likely contains a signal peptide sequence that requires cleavage by proteolytic enzymes in order to become biologically active. While expressed at low levels in testis, ∫-defensin 121 is abundantly expressed in epididymal caput and corpus and, unlike other ∫-defensins, it does not appear to be regulated by androgens.
Caculated MW:   8 kDa
Observed MW:   Refer to Figures
Applications:   WB 1:500-1:2000
IHC 1:50-1:200
Reacitivity:   Human
For research use only. Not intended for diagnostic or therapeutic use!
Additional information