ARP130399-61 [Polyclonal Antibody]
ACVR1C Rabbit Polyclonal Antibody
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Species:   Rabbit
Applications:   WB IHC
Immunogen Range:   A recombinant protein of human ACVR1C
Clonality:   Polyclonal Antibody
Isotype:   IgG
GENE ID:   130399
Swiss Prot:   Q8NER5
Synonyms:   ACVR1C,ACVRLK7,ALK7
Purification:   Affinity purification
Storage:   Store at -20°C or -80°C in PBS with 0.02% sodium azide and 50% glycerol. Avoid freeze/thaw cycles.
Background:   ACTR-IC (Activin receptor type 1C), also referred to as Activin receptor-like kinase 7 (ALK-7), is a type I serine/threonine kinase receptor. ACTA-IC contains an extracellular binding domain, an intracellular serine/threonine kinase domain preceded by a GS box and a transmembrane domain. It is expressed throughout the digestive and central nervous system and localizes to the cell surface. Four ACTR-IC transcripts are generated by alternative splicing. Transcript 1 is the functional full length receptor, transcript 2 lacks a complete receptor binding domain and transcripts 3 and 4 are soluble proteins that lack a transmembrane domain. ACTR-IC is a receptor for Activin AB, Activin B and Nodal. In pancreatic cells, ACTR-IC forms a complex with Activin receptor type IIB (ACTR-IIB). The kinase domain of ACTR-IC can induce Smad2 and Smad3 signalling pathways. In some cell lines, ACTR-IC overexpression induces apoptosis and inhibits proliferation.
Caculated MW:   55 kDa
Observed MW:   Refer to Figures
Applications:   WB 1:500-1:2000
IHC 1:50-1:200
Reacitivity:   Human, Mouse, Rat
For research use only. Not intended for diagnostic or therapeutic use!
Additional information