ARP1630-61 [Polyclonal Antibody]
DCC Rabbit Polyclonal Antibody
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Species:   Rabbit
Applications:   IF ICC
Immunogen Range:   A synthetic peptide
Clonality:   Polyclonal Antibody
Isotype:   IgG
GENE ID:   1630
Swiss Prot:   P43146
Synonyms:   colorectal cancer suppressor, deleted in colorectal carcinoma, netrin receptor DCC, tumor suppressor protein DCC
Purification:   Affinity purification
Storage:   Store at -20°C or -80°C in PBS with 0.02% sodium azide and 50% glycerol. Avoid freeze/thaw cycles.
Background:   This gene encodes a netrin 1 receptor. The transmembrane protein is a member of the immunoglobulin superfamily of cell adhesion molecules, and mediates axon guidance of neuronal growth cones towards sources of netrin 1 ligand. The cytoplasmic tail interacts with the tyrosine kinases Src and focal adhesion kinase (FAK, also known as PTK2) to mediate axon attraction. The protein partially localizes to lipid rafts, and induces apoptosis in the absence of ligand. The protein functions as a tumor suppressor, and is frequently mutated or downregulated in colorectal cancer and esophageal carcinoma. [provided by RefSeq, Oct 2009]
Caculated MW:   158 kDa
Observed MW:   Refer to Figures
Applications:   IF 1:100-1:500
ICC 1:100-1:500
Reacitivity:   Human, Mouse, Rat
For research use only. Not intended for diagnostic or therapeutic use!
Additional information