ARP7178-61 [Polyclonal Antibody]
TCTP Rabbit Polyclonal Antibody
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Species:   Rabbit
Applications:   WB IHC
Immunogen Range:   A synthetic peptide
Clonality:   Polyclonal Antibody
Isotype:   IgG
GENE ID:   7178
Swiss Prot:   P13693
Synonyms:   HRF, TCTP, fortilin, histamine-releasing factor, translationally-controlled tumor protein
Purification:   Affinity purification
Storage:   Store at -20°C or -80°C in PBS with 0.02% sodium azide and 50% glycerol. Avoid freeze/thaw cycles.
Background:   Translationally controlled tumor protein (TCTP/p23/HRF) is a ubiquitously expressed and highly conserved protein involved in various cellular processes, such as its role as a histamine releasing factor in chronic allergic disease. TCTP binds tubulin in a cell cycle dependent manner and is associated with the mitotic spindle. In addition, TCTP interacts with the actin cytoskeleton to regulate cell shape. In mitosis, TCTP is phosphorylated by PLK at Ser46, decreasing microtubule stability. TCTP interacts with the small GTPase Rheb, possibly acting as a GEF, thereby activating the TORC1 pathway and controlling cell growth and proliferation. TCTP has also been shown to be involved in apoptosis and cell stress. In cultured cells, reduction in TCTP expression can cause loss of the malignant phenotype.
Caculated MW:   24 kDa
Observed MW:   Refer to Figures
Applications:   WB 1:500-1:1000
IHC 1:50-1:200
Reacitivity:   Human, Mouse, Rat
For research use only. Not intended for diagnostic or therapeutic use!
Additional information