AMM942-61 [Monoclonal Antibody]
CD86 Mouse Monoclonal Antibody
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Species:   Mouse
Applications:   WB ELISA
Immunogen Range:   A purified recombinant fragment of human CD86 expressed in E. Coli
Clonality:   Monoclonal Antibody
Isotype:   IgG1
GENE ID:   942
Swiss Prot:   P42081
Synonyms:   B70, B7-2, LAB72, CD28LG2, MGC34413, CD86
Purification:   Affinity chromatography
Storage:   Store at -20°C or -80°C in PBS with 0.02% sodium azide and 50% glycerol. Avoid freeze/thaw cycles.
Background:   This gene encodes a type I membrane protein that is a member of the immunoglobulin superfamily. This protein is expressed by antigen-presenting cells, and it is the ligand for two proteins at the cell surface of T cells, CD28 antigen and cytotoxic T-lymphocyte-associated protein 4. Binding of this protein with CD28 antigen is a costimulatory signal for activation of the T-cell. Binding of this protein with cytotoxic T-lymphocyte-associated protein 4 negatively regulates T-cell activation and diminishes the immune response. Alternative splicing results in two transcript variants encoding different isoforms. Additional transcript variants have been described, but their full-length sequences have not been determined.Tissue specificity: Expressed by activated B-lymphocytes and monocytes.
Caculated MW:   52 kDa
Observed MW:   Refer to Figures
Applications:   WB 1:500-1:2000
Reacitivity:   Human
For research use only. Not intended for diagnostic or therapeutic use!
Additional information