AMM4593-61 [Monoclonal Antibody]
MUSK Mouse Monoclonal Antibody
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Species:   Mouse
Applications:   IHC ELISA ICC
Immunogen Range:   A purified recombinant fragment of human MUSK expressed in E. Coli
Clonality:   Monoclonal Antibody
Isotype:   IgG1
GENE ID:   4593
Swiss Prot:   O15146
Synonyms:   muscle, skeletal, receptor tyrosine kinase
Purification:   Affinity chromatography
Storage:   Store at -20°C or -80°C in PBS with 0.02% sodium azide and 50% glycerol. Avoid freeze/thaw cycles.
Background:   MuSK (for Muscle Specific Kinase) is a receptor tyrosine kinase required for the formation of the neuromuscular junction (NMJ). It induces cellular signaling by causing the addition of phosphate molecules to particular tyrosines on itself, and on proteins which bind the cytoplasmic domain of the receptor. It is activated by a nerve-derived proteoglycan called agrin. During development, the growing end of motor neuron axons secrete a protein called agrin.This protein binds to several receptors on the surface of skeletal muscle. The receptor which seems to be required for formation of the neuromuscular junction (NMJ), which comprises the nerve-muscle synapse is called MuSK. MUSK mutations lead to decreased agrin-dependent AchR aggregation, a critical step in the formation of the neuromuscular junction.
Caculated MW:   97 kDa
Observed MW:   Refer to Figures
Applications:   IHC 1:200-1:1000
ICC 1:200-1:1000
Reacitivity:   Human
For research use only. Not intended for diagnostic or therapeutic use!
Additional information