AMM5602-61 [Monoclonal Antibody]
MAPK10 Mouse Monoclonal Antibody
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Species:   Mouse
Applications:   WB ELISA ICC
Immunogen Range:   A purified recombinant fragment of human MAPK10 expressed in E. Coli
Clonality:   Monoclonal Antibody
Isotype:   IgG1
GENE ID:   5602
Swiss Prot:   P53779
Synonyms:   EC 2.7.11.24, JNK3-alpha-2, JNK3A, MAP kinase p49 3F12, MAPK10, MK10, Mitogen-activated protein kinase 10, PRKM10, SAPK-beta, SERK2, Stress-activated protein kinase JNK3, c-Jun N-terminal kinase 3, kinase JNK3, p54- beta
Purification:   Affinity chromatography
Storage:   Store at -20°C or -80°C in PBS with 0.02% sodium azide and 50% glycerol. Avoid freeze/thaw cycles.
Background:   The protein encoded by this gene is a member of the MAP kinase family. MAP kinases act as an integration point for multiple biochemical signals, and are involved in a wide variety of cellular processes such as proliferation, differentiation, transcription regulation and development. This protein is a neuronal-specific form of c-Jun N-terminal kinases (JNKs). Through its phosphorylation and nuclear localization, this kinase plays regulatory roles in the signaling pathways during neuronal apoptosis. Beta-arrestin 2, a receptor-regulated MAP kinase scaffold protein, is found to interact with, and stimulate the phosphorylation of this kinase by MAP kinase kinase 4 (MKK4). Cyclin-dependent kianse 5 can phosphorylate, and inhibit the activity of this kinase, which may be important in preventing neuronal apoptosis. Four alternatively spliced transcript variants encoding distinct isoforms have been reported.
Caculated MW:   53 kDa
Observed MW:   Refer to Figures
Applications:   WB 1:500-1:2000
FC 1:200-1:400
Reacitivity:   Human, Mouse
For research use only. Not intended for diagnostic or therapeutic use!
Additional information