Species: | Mouse |
Applications: | WB IHC ELISA ICC FC |
Immunogen Range: | A purified recombinant fragment of human MMP9 expressed in E. Coli |
Clonality: | Monoclonal Antibody |
Isotype: | IgG1 |
GENE ID: | 4318 |
Swiss Prot: | P14780 |
Synonyms: | EC 3.4.24.35MMP992 kDa type IV collagenase92 kDa gelatinaseGelatinase BGELB |
Purification: | Affinity chromatography |
Storage: | Store at -20°C or -80°C in PBS with 0.02% sodium azide and 50% glycerol. Avoid freeze/thaw cycles. |
Background: | Proteins of the matrix metalloproteinase (MMP) family are involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, as well as in disease processes, such as arthritis and metastasis. Most MMP's are secreted as inactive proproteins which are activated when cleaved by extracellular proteinases. The enzyme encoded by this gene degrades type IV and V collagens. Studies in rhesus monkeys suggest that the enzyme is involved in IL-8-induced mobilization of hematopoietic progenitor cells from bone marrow, and murine studies suggest a role in tumor-associated tissue remodeling. |
Caculated MW: | 92 kDa |
Observed MW: | Refer to Figures |
Applications: |
WB 1:500-1:2000 IHC 1:200-1:1000 ICC 1:200-1:1000 FC 1:200-1:400 |
Reacitivity: | Human |