AMM367-61 [Monoclonal Antibody]
AR Mouse Monoclonal Antibody
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Species:   Mouse
Applications:   WB ELISA
Immunogen Range:   A purified recombinant fragment of human AR expressed in E. Coli
Clonality:   Monoclonal Antibody
Isotype:   IgG1
GENE ID:   367
Swiss Prot:   P10275
Synonyms:   ANDR, Androgen receptor, DHTR, Dihydrotestosterone receptor, NR3C4
Purification:   Affinity chromatography
Storage:   Store at -20°C or -80°C in PBS with 0.02% sodium azide and 50% glycerol. Avoid freeze/thaw cycles.
Background:   The androgen receptor gene is more than 90 kb long and codes for a protein that has 3 major functional domains: the N-terminal domain, DNA-binding domain, and androgen-binding domain. The protein functions as a steroid-hormone activated transcription factor. Upon binding the hormone ligand, the receptor dissociates from accessory proteins, translocates into the nucleus, dimerizes, and then stimulates transcription of androgen responsive genes. This gene contains 2 polymorphic trinucleotide repeat segments that encode polyglutamine and polyglycine tracts in the N-terminal transactivation domain of its protein. Expansion of the polyglutamine tract causes spinal bulbar muscular atrophy (Kennedy disease). Mutations in this gene are also associated with complete androgen insensitivity (CAIS). Two alternatively spliced variants encoding distinct isoforms have been described.
Caculated MW:   99 kDa
Observed MW:   Refer to Figures
Applications:   WB 1:500-1:2000
Reacitivity:   Human
For research use only. Not intended for diagnostic or therapeutic use!
Additional information