Species: | Mouse |
Applications: | WB ELISA ICC FC |
Immunogen Range: | A purified recombinant fragment of human JAK3 expressed in E. Coli |
Clonality: | Monoclonal Antibody |
Isotype: | IgG1 |
GENE ID: | 3718 |
Swiss Prot: | P52333 |
Synonyms: | EC 2.7.10.2, JAK-3, JAK3, Janus kinase 3, L-JAK, Leukocyte janus kinase, kinase Jak3 |
Purification: | Affinity chromatography |
Storage: | Store at -20°C or -80°C in PBS with 0.02% sodium azide and 50% glycerol. Avoid freeze/thaw cycles. |
Background: | JAK3, Janus kinase 3. It is a member of the Janus kinase (JAK) family of tyrosine kinases involved in cytokine receptor-mediated intracellular signal transduction. It is predominantly expressed in immune cells and transduces a signal in response to its activation via tyrosine phosphorylation by interleukin receptors. Mutations in this gene are associated with autosomal SCID (severe combined immunodeficiency disease). |
Caculated MW: | 125 kDa |
Observed MW: | Refer to Figures |
Applications: |
WB 1:500-1:2000 ICC 1:200-1:1000 FC 1:200-1:400 |
Reacitivity: | Human, Mouse |