AMM1576-61 [Monoclonal Antibody]
CYP3A4 Mouse Monoclonal Antibody
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Species:   Mouse
Applications:   WB IHC ELISA ICC FC
Immunogen Range:   A purified recombinant fragment of human CYP3A4 expressed in E. Coli
Clonality:   Monoclonal Antibody
Isotype:   IgG1
GENE ID:   1576
Swiss Prot:   P08684
Synonyms:   Cytochrome P450 3A4, EC 1.14.13.67, Quinine 3-monooxygenase, CYPIIIA4, Nifedipine oxidase, Nifedipine oxidase, Cytochrome P450 3A3, CYPIIIA3, HLp, Taurochenodeoxycholate 6-alpha-hydroxylase, EC 1.14.13.97, NF-25, P450-PCN1, CYP3A3, CP3A4
Purification:   Affinity chromatography
Storage:   Store at -20°C or -80°C in PBS with 0.02% sodium azide and 50% glycerol. Avoid freeze/thaw cycles.
Background:   This gene, CYP3A4, encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein localizes to the endoplasmic reticulum and its expression is induced by glucocorticoids and some pharmacological agents. This enzyme is involved in the metabolism of approximately half the drugs which are are used today, including acetaminophen, codeine, cyclosporin A, diazepam and erythromycin. The enzyme also metabolizes some steroids and carcinogens. This gene is part of a cluster of cytochrome P450 genes on chromosome 7q21.1. Previously another CYP3A gene, CYP3A3, was thought to exist; however, it is now thought that this sequence represents a transcript variant of CYP3A4.
Caculated MW:   57 kDa
Observed MW:   Refer to Figures
Applications:   WB 1:500-1:2000
IHC 1:200-1:1000
ICC 1:200-1:1000
FC 1:200-1:400
Reacitivity:   Human
For research use only. Not intended for diagnostic or therapeutic use!
Additional information