AMM112939-61
[Monoclonal Antibody]
NACC1 Mouse Monoclonal Antibody
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Species: |
Mouse |
Applications: |
WB IHC ELISA |
Immunogen Range: |
A purified recombinant fragment of human NACC1 expressed in E. Coli |
Clonality: |
Monoclonal Antibody |
Isotype: |
IgG1 |
GENE ID: |
112939 |
Swiss Prot: |
Q96RE7 |
Synonyms: |
NAC1, BEND8, NAC-1, BTBD14B, FLJ37383, NACC1 |
Purification: |
Affinity chromatography |
Storage: |
Store at -20°C or -80°C in PBS with 0.02% sodium azide and 50% glycerol. Avoid freeze/thaw cycles. |
Background: |
NAC1 or nuclear accumbens-1 is a nuclear factor that belongs to the POZ/BTB (Pox virus and zinc finger/bric-a-brac tramtrack broad complex) domain family. Also known as BTBD14B, it was originally identified in a unique neuronal forebrain structure responsible for reward motivation and addictive behaviors . NAC1 recruits HDAC3 and HDAC4 to transcriptionally repress gene expression in neuronal cells (3) and specifically co-represses other POZ/BTB proteins in the central nervous system . NAC1 is upregulated in several tumor types, including breast, renal cell, and hepatocellular carcinoma, as well as high grade ovarian serous carcinoma, where it has long been suspected as a chemoresistance gene . The chemoresistance mechanism reportedly occurs through NAC1 negative regulation of the GADD45 pathway . NAC1 has also been described as part of the extended transcriptional network in pluripotent cells that involves Oct-4, Sox2, Nanog, Sall1, KLF4 and Sall4 . |
Caculated MW: |
58 kDa |
Observed MW: |
Refer to Figures |
Applications: |
WB 1:500-1:2000 IHC 1:200-1:1000
|
Reacitivity: |
Human |
For research use only. Not intended for diagnostic or therapeutic use!