Species: | Mouse |
Applications: | WB IHC ELISA ICC FC |
Immunogen Range: | A purified recombinant fragment of human SMAD5 expressed in E. Coli |
Clonality: | Monoclonal Antibody |
Isotype: | IgG1 |
GENE ID: | 4090 |
Swiss Prot: | Q99717 |
Synonyms: | Dwfc, JV5-1, MADH5, DKFZp781C1895, DKFZp781O1323, SMAD5 |
Purification: | Affinity chromatography |
Storage: | Store at -20°C or -80°C in PBS with 0.02% sodium azide and 50% glycerol. Avoid freeze/thaw cycles. |
Background: | Transcriptional modulator activated by BMP (bone morphogenetic proteins) type 1 receptor kinase. SMAD5 is a receptor-regulated SMAD (R-SMAD). SMAD5 is required for normal development of the cardiovascular system in vivo; lack of the SMAD5 gene results in apoptosis of cardiac myocytes. 3 Upregulation of SMAD5 has been reported to mediate apoptosis of gastric epithelial cells induced by Helicobacter pylori infection. Tissue specificity: Ubiquitous. |
Caculated MW: | 52 kDa |
Observed MW: | Refer to Figures |
Applications: |
WB 1:500-1:2000 IHC 1:200-1:1000 ICC 1:200-1:1000 FC 1:200-1:400 |
Reacitivity: | Human, Rat |