ARP5295-62 [Polyclonal Antibody]
PI3 kinase P85α Rabbit Polyclonal Antibody
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Species:   Rabbit
Applications:   WB IHC
Immunogen Range:   A synthetic peptide derived from human PI3 kinase P85α
Clonality:   Polyclonal Antibody
Isotype:   IgG
GENE ID:   5295
Swiss Prot:   P27986
Synonyms:   GRB1, P85A, phosphatidylinositol 3-kinase regulatory alpha subunit, PI3-kinase p85-alpha, PI3K, PI3K p85-alpha, ptdIns-3-kinase p85-alpha
Purification:   Affinity purification
Storage:   Store at -20°C or -80°C in PBS with 0.02% sodium azide and 50% glycerol. Avoid freeze/thaw cycles.
Background:   Binds to activated (phosphorylated) protein-Tyr kinases, through its SH2 domain, and acts as an adapter, mediating the association of the p110 catalytic unit to the plasma membrane. Necessary for the insulin-stimulated increase in glucose uptake and glycogen synthesis in insulin-sensitive tissues. Plays an important role in signaling in response to FGFR1, FGFR2, FGFR3, FGFR4, KITLG/SCF, KIT, PDGFRA and PDGFRB. Likewise, plays a role in ITGB2 signaling.
Caculated MW:   83 kDa
Observed MW:   Refer to Figures
Applications:   WB 1:500-1:2000
IHC 1:50-1:200
Reacitivity:   Human, Mouse, Rat
For research use only. Not intended for diagnostic or therapeutic use!
Additional information