ARP1869-62 [Polyclonal Antibody]
E2F-1 Rabbit Polyclonal Antibody
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Species:   Rabbit
Applications:   WB
Immunogen Range:   Peptide sequence around aa.430~434(G-D-L-T-P) derived from Human E2F-1
Clonality:   Polyclonal Antibody
Isotype:   IgG
GENE ID:   1869
Swiss Prot:   Q01094
Synonyms:   RBP3, E2F-1, RBAP1, RBBP3
Purification:   Affinity purification
Storage:   Store at -20°C or -80°C in PBS with 0.02% sodium azide and 50% glycerol. Avoid freeze/thaw cycles.
Background:   Transcription activator that binds DNA cooperatively with dp proteins through the E2 recognition site, 5'-TTTC[CG]CGC-3' found in the promoter region of a number of genes whose products are involved in cell cycle regulation or in DNA replication. The DRTF1/E2F complex functions in the control of cell-cycle progression from G1 to S phase. E2F-1 binds preferentially RB1 protein, in a cell-cycle dependent manner. It can mediate both cell proliferation and p53-dependent apoptosis. "P53 and E2F-1 cooperate to mediate apoptosis."
Caculated MW:   70 kDa
Observed MW:   Refer to Figures
Applications:   WB 1:500-1:2000
Reacitivity:   Human, Mouse
For research use only. Not intended for diagnostic or therapeutic use!
Additional information