ARP6774P-61 [Polyclonal Antibody]
Phospho-STAT3-Tyr705 Rabbit Polyclonal Antibody
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Species:   Rabbit
Applications:   WB IHC IP
Immunogen Range:   A synthetic peptide derived from human STAT3 around the phosphorylation site of Tyrosine 705
Clonality:   Polyclonal Antibody
Isotype:   IgG
GENE ID:   6774
Swiss Prot:   P40763
Synonyms:   APRF, HIES
Purification:   Affinity purification
Storage:   Store at -20°C or -80°C in PBS with 0.02% sodium azide and 50% glycerol. Avoid freeze/thaw cycles.
Background:   The protein encoded by this gene is a member of the STAT protein family. In response to cytokines and growth factors, STAT family members are phosphorylated by the receptor associated kinases, and then form homo- or heterodimers that translocate to the cell nucleus where they act as transcription activators. This protein is activated through phosphorylation in response to various cytokines and growth factors including IFNs, EGF, IL5, IL6, HGF, LIF and BMP2. This protein mediates the expression of a variety of genes in response to cell stimuli, and thus plays a key role in many cellular processes such as cell growth and apoptosis. The small GTPase Rac1 has been shown to bind and regulate the activity of this protein. PIAS3 protein is a specific inhibitor of this protein. Three alternatively spliced transcript variants encoding distinct isoforms have been described.
Caculated MW:   86 kDa
Observed MW:   Refer to Figures
Applications:   WB 1:500-1:2000
IHC 1:50-1:200
Reacitivity:   Human, Mouse, Rat
For research use only. Not intended for diagnostic or therapeutic use!
Additional information