Species: | Rabbit |
Applications: | IHC IF ICC |
Immunogen Range: | A synthetic peptide derived from human Collagen XVIIIalpha 1 |
Clonality: | Polyclonal Antibody |
Isotype: | IgG |
GENE ID: | 80781 |
Swiss Prot: | P39060 |
Synonyms: | Collagen alpha-1(XVIII) chain [Precursor], Endostatin, COIA1 |
Purification: | Affinity purification |
Storage: | Store at -20°C or -80°C in PBS with 0.02% sodium azide and 50% glycerol. Avoid freeze/thaw cycles. |
Background: | This gene encodes the alpha chain of type XVIII collagen. This collagen is one of the multiplexins, extracellular matrix proteins that contain multiple triple-helix domains (collagenous domains) interrupted by non-collagenous domains. The proteolytically produced C-terminal fragment of type XVIII collagen is endostatin, a potent antiangiogenic protein. Mutations in this gene are associated with Knobloch syndrome. The main features of this syndrome involve retinal abnormalities so type XVIII collagen may play an important role in retinal structure and in neural tube closure. Three transcripts have been identified for this gene. |
Caculated MW: | 178 kDa |
Observed MW: | Refer to Figures |
Applications: |
IHC 1:50-1:200 IF 1:100-1:500 ICC 1:100-1:500 |
Reacitivity: | Human, Mouse |