ARP10614-61
[Polyclonal Antibody]
HEXIM1 Rabbit Polyclonal Antibody
www.yhsbio.com
market@yhsbio.com
support@yhsbio.com
+86-21-54651191
Room 703,Building 6,333# Guiping
Rd.,Xuhui District,Shanghai,China
market@yhsbio.com
support@yhsbio.com
+86-21-54651191
Room 703,Building 6,333# Guiping
Rd.,Xuhui District,Shanghai,China
DATASHEET
| Species: | Rabbit |
| Applications: | WB IF ICC |
| Immunogen Range: | A synthetic peptide derived from human HEXIM1 |
| Clonality: | Polyclonal Antibody |
| Isotype: | IgG |
| GENE ID: | 10614 |
| Swiss Prot: | O94992 |
| Synonyms: | Cardiac lineage protein 1, CLP1, EDG1, Estrogen down-regulated gene 1 protein, FLJ13562, hexamethylene bis-acetamide inducible 1, Hexamethylene bis-acetamide-inducible protein 1, hexamethylene bisacetamide-inducible protein, hexamethylene-bis-acetamide-in |
| Purification: | Affinity purification |
| Storage: | Store at -20°C or -80°C in PBS with 0.02% sodium azide and 50% glycerol. Avoid freeze/thaw cycles. |
| Background: | HEXIM1 Transcriptional regulator which functions as a general RNA polymerase II transcription inhibitor. In cooperation with 7SK snRNA sequesters P-TEFb in a large inactive 7SK snRNP complex preventing RNA polymerase II phosphorylation and subsequent transcriptional elongation. May also regulate NF-kappa-B, ESR1, NR3C1 and CIITA-dependent transcriptional activity. Homooligomer and heterooligomer with HEXIM2; probably dimeric. Component of the 7SK snRNP complex at least composed of P-TEFb (composed of CDK9 and CCNT1/cyclin-T1), HEXIM1, HEXIM2, BCDIN3, SART3 proteins and 7SK and U6 snRNAs. Interacts with the N-CoR complex through NCOR1. |
| Caculated MW: | 40 kDa |
| Observed MW: | Refer to Figures |
| Applications: |
WB 1:500-1:2000 IF 1:100-1:500 ICC 1:100-1:500 |
| Reacitivity: | Human, Mouse, Rat |
For research use only. Not intended for diagnostic or therapeutic use!
Additional information
