Species: | Rabbit |
Applications: | WB IHC IF ICC |
Immunogen Range: | A synthetic peptide derived from human TFIP8 |
Clonality: | Polyclonal Antibody |
Isotype: | IgG |
GENE ID: | 25816 |
Swiss Prot: | O95379 |
Synonyms: | GG2-1, Head and neck tumor and metastasis-related protein, MDC-3.13, NDED, NF-kappa-B-inducible DED-containing protein, SCC-S2, SCCS2, TFIP8, TNF alpha-induced protein 8, TNF-induced protein GG2-1, TNFAIP8, Tumor necrosis factor alpha-induced protein 8, t |
Purification: | Affinity purification |
Storage: | Store at -20°C or -80°C in PBS with 0.02% sodium azide and 50% glycerol. Avoid freeze/thaw cycles. |
Background: | TNFAIP8 Acts as a negative mediator of apoptosis and may play a role in tumor progression. Suppresses the TNF-mediated apoptosis by inhibiting caspase-8 activity but not the processing of procaspase-8, subsequently resulting in inhibition of BID cleavage and caspase-3 activation. Belongs to the TNFAIP8 family. Induced by nuclear factor-KB (NF-KB) and TNF. Induction by TNF depends upon activation of NF-KB. |
Caculated MW: | 23 kDa |
Observed MW: | Refer to Figures |
Applications: |
WB 1:500-1:2000 IHC 1:50-1:200 IF 1:100-1:500 ICC 1:100-1:500 |
Reacitivity: | Human, Mouse |