Species: | Rabbit |
Applications: | WB IF ICC |
Immunogen Range: | A synthetic peptide derived from human HEC1 |
Clonality: | Polyclonal Antibody |
Isotype: | IgG |
GENE ID: | 10403 |
Swiss Prot: | O14777 |
Synonyms: | HEC, HEC1, Highly expressed in cancer protein, highly expressed in cancer, rich in leucine heptad repeats, HsHec1, hsNDC80, kinetochore associated 2, Kinetochore protein Hec1, Kinetochore protein NDC80 homolog, Kinetochore-associated protein 2, KNTC2, NDC |
Purification: | Affinity chromatography |
Storage: | Store at -20°C or -80°C in PBS with 0.02% sodium azide and 50% glycerol. Avoid freeze/thaw cycles. |
Background: | HEC1 plays an essential role in chromosome segregation by interacting through its coiled-coil domains with several proteins that modulate the G2/M phase. Phosphorylation by Nek2 is essential for faithful chromosome segregation. Required for the recruitment of Mps1 kinase and Mad1/Mad2 complexes to kinetochores. |
Caculated MW: | 73 kDa |
Observed MW: | Refer to Figures |
Applications: |
WB 1:500-1:3000 IF 1:100-1:500 ICC 1:100-1:500 |
Reacitivity: | Human, Mouse |