ARP140885-61 [Polyclonal Antibody]
SHPS1 Rabbit Polyclonal Antibody
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Species:   Rabbit
Applications:   WB IHC
Immunogen Range:   A synthetic peptide derived from human SHPS1
Clonality:   Polyclonal Antibody
Isotype:   IgG
GENE ID:   140885
Swiss Prot:   P78324
Synonyms:   BIT, Brain Ig-like molecule with tyrosine-based activation motifs, brain-immunoglobulin-like molecule with tyrosine-based activation motifs, CD172 antigen-like family member A, CD172A, Inhibitory receptor SHPS-1, Macrophage fusion receptor, MFR, MYD-1, M
Purification:   Affinity chromatography
Storage:   Store at -20°C or -80°C in PBS with 0.02% sodium azide and 50% glycerol. Avoid freeze/thaw cycles.
Background:   SHPS1 Immunoglobulin-like cell surface receptor for CD47. Acts as docking protein and induces translocation of PTPN6, PTPN11 and other binding partners from the cytosol to the plasma membrane. Supports adhesion of cerebellar neurons, neurite outgrowth and glial cell attachment. May play a key role in intracellular signaling during synaptogenesis and in synaptic function. Involved in the negative regulation of receptor tyrosine kinase-coupled cellular responses induced by cell adhesion, growth factors or insulin. Mediates negative regulation of phagocytosis, mast cell activation and dendritic cell activation.
Caculated MW:   55 kDa
Observed MW:   Refer to Figures
Applications:   WB 1:500-1:3000
IHC 1:50-1:200
Reacitivity:   Human, Mouse, Rat
For research use only. Not intended for diagnostic or therapeutic use!
Additional information