Species: | Mouse |
Applications: | WB IHC IF ICC |
Immunogen Range: | A synthetic peptide derived from human p14 ARF |
Clonality: | Polyclonal Antibody |
Isotype: | IgG1 Kappa |
GENE ID: | 1029 |
Swiss Prot: | Q8N726 |
Synonyms: | CDKN4, KIP1, MEN1B, MEN4, P27KIP1 |
Purification: | Affinity purification |
Storage: | Store at 4°C in PBS, pH 7.4 (protein base, sodium azide). |
Background: | This gene encodes a cyclin-dependent kinase inhibitor, which shares a limited similarity with CDK inhibitor CDKN1A/p21. The encoded protein binds to and prevents the activation of cyclin E-CDK2 or cyclin D-CDK4 complexes, and thus controls the cell cycle progression at G1. The degradation of this protein, which is triggered by its CDK dependent phosphorylation and subsequent ubiquitination by SCF complexes, is required for the cellular transition from quiescence to the proliferative state. [provided by RefSeq |
Caculated MW: | 18 kDa |
Observed MW: | Refer to Figures |
Applications: |
WB 1:500-1:3000 IHC 1:50-1:200 IF 1:100-1:500 ICC 1:100-1:500 |
Reacitivity: | Human |